Relationship among genetic variants, obesity traits and asthma in the Taiwan Biobank.

ABSTRACT:

Background and objective

Obesity and asthma impose a heavy health and economic burden on millions of people around the world. The complex interaction between genetic traits and phenotypes caused the mechanism between obesity and asthma is still vague. This study investigates the relationship among obesity-related polygenic risk score (PRS), obesity phenotypes and the risk of having asthma.

Methods

This is a matched case-control study, with 4 controls (8288 non-asthmatic) for each case (2072 asthmatic). Data were obtained from the 2008-2015 Taiwan Biobank Database and linked to the 2000-2016 National Health Insurance Research Database. All participants were ≥30 years old with no history of cancer and had a complete questionnaire, as well as physical examination, genome-wide s

SUBMITTER: Huang YJ 

PROVIDER: S-EPMC9730389 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature