Ontology highlight
ABSTRACT:
SUBMITTER: Huang S
PROVIDER: S-EPMC9730451 | biostudies-literature | 2022 Nov
REPOSITORIES: biostudies-literature
Huang Shijiao S Haga Yoshimi Y Li Jie J Zhang Jianchao J Kweon Hye Kyong HK Seino Junichi J Hirayama Hiroto H Fujita Morihisa M Moremen Kelley W KW Andrews Philip P Suzuki Tadashi T Wang Yanzhuang Y
Cell reports 20221101 8
N-glycans are processed mainly in the Golgi, and a well-organized Golgi structure is required for accurate glycosylation. However, during mitosis the Golgi undergoes severe fragmentation. The resulting trafficking block leads to an extended exposure of cargo molecules to Golgi enzymes. It is unclear how cells avoid glycosylation defects during mitosis. In this study, we report that Golgi α-1,2-mannosidase IA (MAN1A1), the first enzyme that cargo proteins encounter once arriving the Golgi, is pho ...[more]