Comparative epigenomics reveals the impact of ruminant-specific regulatory elements on complex traits.

ABSTRACT:

Background

Insights into the genetic basis of complex traits and disease in both human and livestock species have been achieved over the past decade through detection of genetic variants in genome-wide association studies (GWAS). A majority of such variants were found located in noncoding genomic regions, and though the involvement of numerous regulatory elements (REs) has been predicted across multiple tissues in domesticated animals, their evolutionary conservation and effects on complex traits have not been fully elucidated, particularly in ruminants. Here, we systematically analyzed 137 epigenomic and transcriptomic datasets of six mammals, including cattle, sheep, goats, pigs, mice, and humans, and then integrated them with large-scale GWAS of complex traits.

Results

Us

SUBMITTER: Chen S 

PROVIDER: S-EPMC9730597 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature