Notch signaling pathway: a comprehensive prognostic and gene expression profile analysis in breast cancer.

ABSTRACT: Breast cancer is a complex disease exhibiting a great degree of heterogeneity due to different molecular subtypes. Notch signaling regulates the differentiation of breast epithelial cells during normal development and plays a crucial role in breast cancer progression through the abnormal expression of the Notch up-and down-stream effectors. To date, there are only a few patient-centered clinical studies using datasets characterizing the role of Notch signaling pathway regulators in breast cancer; thus, we investigate the role and functionality of these factors in different subtypes using publicly available databases containing records from large studies. High-throughput genomic data and clinical information extracted from TCGA were analyzed. We performed Kaplan-Meier survival and different

SUBMITTER: Yousefi H 

PROVIDER: S-EPMC9730604 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature