Genetically predicted testosterone and cancers risk in men: a two-sample Mendelian randomization study.

ABSTRACT:

Objective

In observational studies, testosterone has been reported to be associated with some types of cancers. However, the direction and magnitude of the causal association between testosterone and different types of cancer remain unclear. This Mendelian randomization study assessed the causal associations of total testosterone (TT) and bioavailable testosterone (BT) with cancer risk in men.

Methods

We performed two-sample Mendelian randomization using publicly available GWAS summary statistics to investigate the genetically causal association between testosterone and the risk of 22 kinds of cancers in men. Causal estimates were calculated by the inverse variance weighted method. We also performed additional sensitivity tests to evaluate the validity of the casualty.

Re

SUBMITTER: Chang J 

PROVIDER: S-EPMC9730605 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature