Comprehensive characterization of putative genetic influences on plasma metabolome in a pediatric cohort.

ABSTRACT:

Background

The human exposome is composed of diverse metabolites and small chemical compounds originated from endogenous and exogenous sources, respectively. Genetic and environmental factors influence metabolite levels, while the extent of genetic contributions across metabolic pathways is not yet known. Untargeted profiling of human metabolome using high-resolution mass spectrometry (HRMS) combined with genome-wide genotyping allows comprehensive identification of genetically influenced metabolites. As such previous studies of adults discovered and replicated genotype-metabotype associations. However, these associations have not been characterized in children.

Results

We conducted the largest genome by metabolome-wide association study to date of children (N = 441) using 6

SUBMITTER: Lee IH 

PROVIDER: S-EPMC9730628 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature