Effects of airway pressure release ventilation on multi-organ injuries in severe acute respiratory distress syndrome pig models.

ABSTRACT:

Background

Extra-pulmonary multi-organ failure in patients with severe acute respiratory distress syndrome (ARDS) is a major cause of high mortality. Our purpose is to assess whether airway pressure release ventilation (APRV) causes more multi-organ damage than low tidal volume ventilation (LTV).

Methods

Twenty one pigs were randomized into control group (n = 3), ARDS group (n = 3), LTV group (n = 8) and APRV group (n = 7). Severe ARDS model was induced by repeated bronchial saline lavages. Pigs were ventilated and monitored continuously for 48 h. Respiratory data, hemodynamic data, serum inflammatory cytokines were collected throughout the study. Histological injury and apoptosis were assessed by two pathologists.

Results

After severe ARDS modeling, pigs in ARDS, LTV

SUBMITTER: Ma A 

PROVIDER: S-EPMC9730639 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature