Dataset Information

Treatment outcomes and costs of a simplified antiretroviral treatment strategy for hepatitis C among Hepatitis C Virus and Human Immuno deficiency Virus co-infected patients in Ukraine.

ABSTRACT:

Background and aim

To demonstrate the use of a standard dose of ledipasvir (LDV) and sofosbuvir (SOF), with or without ribavirin, to treat hepatitis C and hepatitis C/HIV co-infection in Ukraine.

Methods

Eligible HCV viraemic adults from two clinics in Kyiv were treated with LDV/SOF with or without weight-based ribavirin for 12 weeks. Clinical assessments were performed at screening and at week 24, and as needed; treatment was dispensed every 4 weeks. The primary outcome was sustained virologic response (SVR) 12 weeks after treatment, with analysis by intention to treat. Cost per patient was estimated in USD (2018) over the 24-week period.

Results

Of 868 patients included in the study and initiated on therapy, 482 (55.5%) were co-infected with HIV. The common genotypes were 1 (74.1%) and 3 (22%). Overall, SVR was achieved in 831 of the 868 patients (95.7%). SVR in patients with hepatitis C alone and hepatitis C/HIV co-infection was 98.4% and 93.6%, respectively. Adverse events were infrequent and usually mild. Using generic medication, cost per patient was estimated at US$680.

Conclusion

A standard dose of LDV and SOF, with ribavirin as per protocol, resulted in good outcomes for patients with both hepatitis C alone and co-infected with hepatitis C/HIV. Program costs in Ukraine were modest using generic medication.

SUBMITTER: Antoniak S

PROVIDER: S-EPMC9730727 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature

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Publications

Treatment outcomes and costs of a simplified antiretroviral treatment strategy for hepatitis C among Hepatitis C Virus and Human Immuno deficiency Virus co-infected patients in Ukraine.

Antoniak Sergie S Chasela Charles S CS Freiman Morgan Julie MJ Stopolianska Yulia Y Barnard Tetiana T Gandhi Malini M MM Liulchuk Maria M Tsenilova Zhanna Z Viktor Tretiakov T Dible Jeri J Wose Kinge Constance C Akpan Francis F Minior Thomas T Sigwebela Ntombi N Mohamed Sofiane S Mohamed Sofiane S Barralon Matthiue M Marange Fadzai F Cavenaugh Clint C Horst Charles Vander CV Antonyak Svitlana S Xulu Thembisile T Chew Kara W KW Sanne Ian I Rosen Sydney S

JGH open : an open access journal of gastroenterology and hepatology 20221117 12

<h4>Background and aim</h4>To demonstrate the use of a standard dose of ledipasvir (LDV) and sofosbuvir (SOF), with or without ribavirin, to treat hepatitis C and hepatitis C/HIV co-infection in Ukraine.<h4>Methods</h4>Eligible HCV viraemic adults from two clinics in Kyiv were treated with LDV/SOF with or without weight-based ribavirin for 12 weeks. Clinical assessments were performed at screening and at week 24, and as needed; treatment was dispensed every 4 weeks. The primary outcome was susta ...[more]

PMID: 36514496

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Dataset Information

Treatment outcomes and costs of a simplified antiretroviral treatment strategy for hepatitis C among Hepatitis C Virus and Human Immuno deficiency Virus co-infected patients in Ukraine.

Background and aim

Methods

Results

Conclusion

Publications

Treatment outcomes and costs of a simplified antiretroviral treatment strategy for hepatitis C among Hepatitis C Virus and Human Immuno deficiency Virus co-infected patients in Ukraine.

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