Transcriptome analysis reveals potential marker genes for diagnosis of Alzheimer's disease and vascular dementia.

ABSTRACT: Alzheimer's disease (AD) and vascular dementia (VD) are the two most common forms of dementia, share similar symptoms, and are sometimes difficult to distinguish. To investigate the potential mechanisms by which they differ, we identified differentially expressed genes in blood and brain samples from patients with these diseases, and performed weighted gene co-expression network analysis and other bioinformatics analyses. Weighted gene co-expression network analysis resulted in mining of different modules based on differences in gene expression between these two diseases. Enrichment analysis and generation of a protein-protein interaction network were used to identify core pathways for each disease. Modules were significantly involved in cAMP and AMPK signaling pathway, which may be regula

SUBMITTER: Wang L 

PROVIDER: S-EPMC9730885 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature