Preparation of Surface-Supported Polylactide Spherical-Cap Particles.

ABSTRACT: Biodegradable polymer particles are of considerable importance due to their multiple applications in medical diagnostics and therapy. Spherical-cap particles have been prepared in a very general and simple method by melting a thin polymer film supported on a solid substrate that is in contact with a hydrophilic solvent. The melted polymer forms droplets which transform into solid particles attached to the surface after cooling down the sample. This approach has been demonstrated for polylactide adlayers on glass, which, when melted in glycerol, produce an array of polymer particles supported on the surface. The size of the particles depends on the experimental conditions and ranges from tens of nanometers to several micrometers. The particles can be employed to incorporate guest species, f

SUBMITTER: Kusmierz B 

PROVIDER: S-EPMC9730905 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature