Validation of ¹⁸F-rhPSMA-7 and ¹⁸F-rhPSMA-7.3 PET Imaging Results with Histopathology from Salvage Surgery in Patients with Biochemical Recurrence of Prostate Cancer.

ABSTRACT: ¹⁸F-rhPSMA-7, and its single diastereoisomer form, ¹⁸F-rhPSMA-7.3, are prostate-specific membrane antigen (PSMA)-targeting radiopharmaceuticals. Here, we investigated their accuracy for the assessment of lymph node (LN) metastases validated by histopathology. Methods: Data from 58 patients with biochemical recurrence of prostate cancer after radical prostatectomy receiving salvage surgery after PET imaging with ¹⁸F-rhPSMA-7 or ¹⁸F-rhPSMA-7.3 were retrospectively reviewed. Two nuclear medicine physicians reviewed all PET scans and morphologic imaging in consensus. Readers were masked from the results of histopathology. PET and morphologic imaging were correlated with histopathology from resected LNs. Results: In 75 of 150 resected re

SUBMITTER: Kroenke M 

PROVIDER: S-EPMC9730917 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature