¹⁸F-FDG PET/CT Staging of Head and Neck Cancer: Interobserver Agreement and Accuracy-Results from Multicenter ACRIN 6685 Clinical Trial.

ABSTRACT: To our knowledge, no prior multicenter clinical trial has reported interobserver agreement of ¹⁸F-FDG PET/CT scans for staging of clinical N0 neck in head and neck cancer. Methods: A total of 287 participants were recruited. For visual analysis, positive nodal uptake of ¹⁸F-FDG was defined as uptake visually greater than activity seen in the blood pool. Results: The negative predictive value of the ¹⁸F-FDG PET/CT for N0 clinical neck was 86% or above for visual assessment (95% CI, 86%-88%) for the 2 central readers and above 90% (95% CI, 90%-95%) for SUV_max for central reads and site reads dichotomized at the optimal cutoff value of 1.8 and the prespecified cutoff value of 3.5, respectively. The κ coefficients between the 2 expert r

SUBMITTER: Subramaniam RM 

PROVIDER: S-EPMC9730921 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature