Development of Fluorinated NP-59: A Revival of Cholesterol Use Imaging with PET.

ABSTRACT: Imaging of cholesterol use is possible with the ¹³¹I scintiscanning/SPECT agent NP-59. This agent provided a noninvasive measure of adrenal function and steroid synthesis. However, iodine isotopes resulted in poor resolution, manufacturing challenges, and high radiation dosimetry to patients that have limited their use and clinical impact. A ¹⁸F analog would address these shortcomings while retaining the ability to image cholesterol use. The goal of this study was to prepare and evaluate a ¹⁸F analog of NP-59 to serve as a PET imaging agent for functional imaging of the adrenal glands based on cholesterol use. Previous attempts to prepare such an analog of NP-59 have proven elusive. Preclinical and clinical evaluation could be performed once the new fluorin

SUBMITTER: Brooks AF 

PROVIDER: S-EPMC9730927 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature