Neoadjuvant therapy in pancreatic neuroendocrine neoplasms: A systematic review and meta-analysis.

ABSTRACT:

Background and objectives

Neoadjuvant therapy plays an increasingly important role in pancreatic neuroendocrine neoplasms (pNENs), but the systematic evaluation of its efficacy is still lacking. The purpose of this study is to explore the role of neoadjuvant therapy in pNENs.

Methods

We systematically reviewed the literatures published online until October 1, 2021. Meta-analysis was conducted to generate proportion with 95% confidence intervals (95% CI) for tumor response, resection rate, R0 resection rate and survival time.

Results

Nine studies with 468 patients were involved in the systematic review. None of these patients met complete response (CR). Furthermore, 43.6% (95% CI [18.1, 69.0]) patients were expected to achieve partial response (PR), 51.3% (95% CI [27.9

SUBMITTER: Li Y 

PROVIDER: S-EPMC9731099 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature