Bioactivity-guided isolation of anti-inflammatory limonins from Chukrasia tabularis.

ABSTRACT: Chukrasia tabularis is an economically important tree and widely cultured in the southeast of China. Its barks, leaves, and fruits are consumed as a traditional medicine and perceived as a valuable source for bioactive limonin compounds. The extracts from root barks of C. tabularis showed significant anti-inflammatory effect. The aim of this research was to explore the material basis of C. tabularis anti-inflammatory activity, and to purify and identify anti-inflammatory active ingredients. By a bioassay-guided isolation of dichloromethane fraction obtained two novel phragmalin limonins, Chukrasitin D and E (1 and 2), together with 12 known limonins (3-14). The chemical structure of these compounds is determined on the basis of extensive spe

SUBMITTER: Shen JH 

PROVIDER: S-EPMC9731525 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature