Inflammation in Children with CKD Linked to Gut Dysbiosis and Metabolite Imbalance.

ABSTRACT:

Background

CKD is characterized by a sustained proinflammatory response of the immune system, promoting hypertension and cardiovascular disease. The underlying mechanisms are incompletely understood but may be linked to gut dysbiosis. Dysbiosis has been described in adults with CKD; however, comorbidities limit CKD-specific conclusions.

Methods

We analyzed the fecal microbiome, metabolites, and immune phenotypes in 48 children (with normal kidney function, CKD stage G3-G4, G5 treated by hemodialysis [HD], or kidney transplantation) with a mean±SD age of 10.6±3.8 years.

Results

Serum TNF-α and sCD14 were stage-dependently elevated, indicating inflammation, gut barrier dysfunction, and endotoxemia. We observed compositional and functional alterations of the micro

SUBMITTER: Holle J 

PROVIDER: S-EPMC9731629 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature