Anatomical Evidence for Parasympathetic Innervation of the Renal Vasculature and Pelvis.

ABSTRACT:

Background

The kidneys critically contribute to body homeostasis under the control of the autonomic nerves, which enter the kidney along the renal vasculature. Although the renal sympathetic and sensory nerves have long been confirmed, no significant anatomic evidence exists for renal parasympathetic innervation.

Methods

We identified cholinergic nerve varicosities associated with the renal vasculature and pelvis using various anatomic research methods, including a genetically modified mouse model and immunostaining. Single-cell RNA sequencing (scRNA-Seq) was used to analyze the expression of AChRs in the renal artery and its segmental branches. To assess the origins of parasympathetic projecting nerves of the kidney, we performed retrograde tracing using recombinant

SUBMITTER: Cheng X 

PROVIDER: S-EPMC9731635 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature