Ontology highlight
ABSTRACT:
SUBMITTER: Li Q
PROVIDER: S-EPMC9731694 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
Li Qiuchen Q Jiang Zhimin Z Ren Shuning S Guo Hui H Song Zhimin Z Chen Saini S Gao Xintao X Meng Fanfeng F Zhu Junda J Liu Litao L Tong Qi Q Sun Honglei H Sun Yipeng Y Pu Juan J Chang Kin-Chow KC Liu Jinhua J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 20221018 34
Splicing of influenza A virus (IAV) RNA is an essential process in the viral life cycle that involves the co-opting of host factors. Here, it is demonstrated that induction of host serine and arginine-rich splicing factor 5 (SRSF5) by IAV facilitated viral replication by enhancing viral M mRNA splicing. Mechanistically, SRSF5 with its RRM2 domain directly bounds M mRNA at conserved sites (M mRNA position 163, 709, and 712), and interacts with U1 small nuclear ribonucleoprotein (snRNP) to promote ...[more]