Globefish-Inspired Balloon Catheter with Intelligent Microneedle Coating for Endovascular Drug Delivery.

ABSTRACT: Balloon catheters exhibit important values in treating cardiovascular diseases, while their functions are still under improvements. Here, inspired by the thorn-hiding and deflating-inflating characteristics of globefish, intelligent balloon catheters decorated with invisible microneedles are presented for endovascular drug delivery to inhibit postintervention restenosis (PIRS). These microneedle balloon catheters (MNBCs) fabricated by dipping and rolling-assisted template replication contain three coating layers of sandwiched drug-carrying microneedles and black phosphorus (BP)-carrying gelatin. During the emplacement, the microneedles of MNBCs are hidden under the outermost gelatin protective layer, allowing smooth movements inside the blood vessel. After reaching the destination, the emb

SUBMITTER: Zhang X 

PROVIDER: S-EPMC9731713 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature