Identification of Diagnostic Markers in Infantile Hemangiomas

ABSTRACT:

Background

Infantile Hemangiomas (IHs) are common benign vascular tumors of infancy that may have serious consequences. The research on diagnostic markers for IHs is scarce.

Methods

The “limma” R package was applied to identify differentially expressed genes (DEGs) in developing IHs. Plugin ClueGO in Cytoscape software performed functional enrichment of DEGs. The Search Tool for Retrieving Interacting Genes (STRING) database was utilized to construct the PPI network. The least absolute shrinkage and selection operator (LASSO) regression model and support vector machine recursive feature elimination (SVM-RFE) analysis were used to identify diagnostic genes for IHs. The receiver operating characteristic (ROC) curve evaluated diagnostic genes' discriminatory ability. Singl

SUBMITTER: Huang S 

PROVIDER: S-EPMC9731762 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature