Associations between disrupted functional brain network topology and cognitive impairment in patients with rectal cancer during chemotherapy.

ABSTRACT:

Introduction

Cognitive impairment has been identified in patients with non-central nervous system cancer received chemotherapy. Chemotherapy-induced changes in the brain are considered as the possible causes of the cognitive deficits of patients. This study aimed to explore chemotherapy-related functional brain changes and cognitive impairment in rectal cancer (RC) patients who had just finished chemotherapy treatment.

Methods

In this study, RC patients after chemotherapy (on the day patients received the last dose of chemotherapy) (n=30) and matched healthy controls (HCs) (n=30) underwent cognitive assessments, structural magnetic resonance imaging (MRI) and resting-state functional MRI. The functional brain networks were constructed by thresholding the partial correlation

SUBMITTER: Guo Y 

PROVIDER: S-EPMC9731768 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature