Associations among Alzheimer disease, depressive disorder, and risk of end-stage kidney disease in elderly people.

ABSTRACT:

Background

Alzheimer disease (AD) and depressive disorder (DD) are prevalent among elderly end-stage kidney disease (ESKD) patients. However, whether preexisting mental health disorders increase the risk of ESKD is not well understood. The risk of incident ESKD in patients with or without underlying AD or DD was evaluated in a nationwide cohort of elderly people in Republic of Korea.

Methods

This study used data from the National Health Insurance Service-Senior cohort in Republic of Korea. Among the 558,147 total subjects, 49,634 and 54,231 were diagnosed with AD (AD group) or DD (DD group), respectively, during the follow-up period. Propensity score matching was conducted to create non-AD and non-DD groups of subjects. AD and DD diagnoses were analyzed as time-varying expos

SUBMITTER: Kang SC 

PROVIDER: S-EPMC9731774 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature