White matter abnormalities in the Hdc knockout mouse, a model of tic and OCD pathophysiology.

ABSTRACT:

Introduction

An inactivating mutation in the histidine decarboxylase gene (Hdc) has been identified as a rare but high-penetrance genetic cause of Tourette syndrome (TS). TS is a neurodevelopmental syndrome characterized by recurrent motor and vocal tics; it is accompanied by structural and functional abnormalities in the cortico-basal ganglia circuitry. Hdc, which is expressed both in the posterior hypothalamus and peripherally, encodes an enzyme required for the biosynthesis of histamine. Hdc knockout mice (Hdc-KO) functionally recapitulate this mutation and exhibit behavioral and neurochemical abnormalities that parallel those seen in patients with TS.

Materials and methods

We performed exploratory RNA-seq to identify pathological altera

SUBMITTER: Jindachomthong K 

PROVIDER: S-EPMC9731796 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature