Teriparatide ameliorates articular cartilage degradation and aberrant subchondral bone remodeling in DMM mice.

ABSTRACT:

Objective

Knee osteoarthritis (KOA) is a highly prevalent musculoskeletal disorder characterized by degeneration of cartilage and abnormal remodeling of subchondral bone (SCB). Teriparatide (PTH (1-34)) is an effective anabolic drug for osteoporosis (OP) and regulates osteoprotegerin (OPG)/receptor activator of nuclear factor ligand (RANKL)/RANK signaling, which also has a therapeutic effect on KOA by ameliorating cartilage degradation and inhibiting aberrant remodeling of SCB. However, the mechanisms of PTH (1-34) in treating KOA are still uncertain and remain to be explored. Therefore, we compared the effect of PTH (1-34) on the post-traumatic KOA mouse model to explore the potential therapeutic effect and mechanisms.

Methods

In vivo study, eight-week-old male mice

SUBMITTER: Li G 

PROVIDER: S-EPMC9731868 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature