Synergistic antibacterial activity of baicalin and EDTA in combination with colistin against colistin-resistant Salmonella.

ABSTRACT: The emergence and rapid spread of multidrug resistant (MDR) Gram-negative bacteria have posed a serious threat to global health and security. Because of the time-consuming, high cost and high risk of developing new antibiotics, a significant method is to use antibiotic adjuvants to revitalize the existing antibiotics. The purpose of the study is to research the traditional Chinese medicine baicalin with the function of inhibiting the efflux pump and EDTA whether their single or combination can increase the activity of colistin against colistin-resistant Salmonella in vitro and in vivo, and to explore its molecular mechanisms. In vitro antibacterial experiments, we have observed that baicalin and EDTA alone could enhance the antibacterial activity of colistin. At the same time, the combinat

SUBMITTER: Cui XD 

PROVIDER: S-EPMC9731884 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature