Developing an internal threshold of toxicological concern (iTTC).

ABSTRACT:

Background

Threshold of Toxicological Concern (TTC) approaches are used for chemical safety assessment and risk-based priority setting for data poor chemicals. TTCs are derived from in vivo No Observed Effect Level (NOEL) datasets involving an external administered dose from a single exposure route, e.g., oral intake rate. Thus, a route-specific TTC can only be compared to a route-specific exposure estimate and such TTCs cannot be used for other exposure scenarios such as aggregate exposures.

Objective

Develop and apply a method for deriving internal TTCs (iTTCs) that can be used in chemical assessments for multiple route-specific exposures (e.g., oral, inhalation or dermal) or aggregate exposures.

Methods

Chemical-specific toxicokinetics (TK) data and models are appl

SUBMITTER: Arnot JA 

PROVIDER: S-EPMC9731903 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature