Filaggrin and cytokines in respiratory samples of preterm infants at risk for respiratory viral infection.

ABSTRACT: Respiratory viral infections (RVIs) are frequent in preterm infants possibly inducing long-term impact on respiratory morbidity. Immune response and respiratory barriers are key defense elements against viral insults in premature infants admitted to Neonatal Intensive Care Units (NICUs). Our main goals were to describe the local immune response in respiratory secretions of preterm infants with RVIs during NICU admission and to evaluate the expression and synthesis of lung barrier regulators, both in respiratory samples and in vitro models. Samples from preterm infants that went on to develop RVIs had lower filaggrin gene and protein levels at a cellular level were compared to never-infected neonates (controls). Filaggrin, MIP-1α/CCL3 and MCP-1 levels were higher in pre-infection supernatan

SUBMITTER: Rodrigo-Munoz JM 

PROVIDER: S-EPMC9731953 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature