Bayesian model and selection signature analyses reveal risk factors for canine atopic dermatitis.

ABSTRACT: Canine atopic dermatitis is an inflammatory skin disease with clinical similarities to human atopic dermatitis. Several dog breeds are at increased risk for developing this disease but previous genetic associations are poorly defined. To identify additional genetic risk factors for canine atopic dermatitis, we here apply a Bayesian mixture model adapted for mapping complex traits and a cross-population extended haplotype test to search for disease-associated loci and selective sweeps in four dog breeds at risk for atopic dermatitis. We define 15 associated loci and eight candidate regions under selection by comparing cases with controls. One associated locus is syntenic to the major genetic risk locus (Filaggrin locus) in human atopic dermatitis. One selection signal in common type Labrado

SUBMITTER: Tengvall K 

PROVIDER: S-EPMC9731970 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature