Ontology highlight
ABSTRACT:
SUBMITTER: Reemst K
PROVIDER: S-EPMC9731997 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
Reemst Kitty K Kracht Laura L Kotah Janssen M JM Rahimian Reza R van Irsen Astrid A S AAS Congrains Sotomayor Gonzalo G Verboon Laura N LN Brouwer Nieske N Simard Sophie S Turecki Gustavo G Mechawar Naguib N Kooistra Susanne M SM Eggen Bart J L BJL Korosi Aniko A
Translational psychiatry 20221208 1
Early-life stress (ELS) leads to increased vulnerability to psychiatric disorders including depression later in life. Neuroinflammatory processes have been implicated in ELS-induced negative health outcomes, but how ELS impacts microglia, the main tissue-resident macrophages of the central nervous system, is unknown. Here, we determined the effects of ELS-induced by limited bedding and nesting material during the first week of life (postnatal days [P]2-9) on microglial (i) morphology; (ii) hippo ...[more]