Pure proton therapy for skull base chordomas and chondrosarcomas: A systematic review of clinical experience

ABSTRACT:

Background

Skull base chordoma and chondrosarcoma are exceptionally rare bone tumors with high propensity for local recurrence. Different postoperative radiation modalities are often used to improve the clinical efficacy. Proton therapy (PT) might be among the most promising ones because of the unique ballistic characteristics of high-energy particles. However, previous meta-analysis often included studies with combined radiation techniques. No systematic review to date has directly analyzed the survival and toxicity of pure PT for these two types of malignancies.

Methods

By following the PRISMA guidelines, a systematic search of three databases was conducted. Articles were screened and data were extracted according to a prespecified scheme. R 4.2.0 software was used to c

SUBMITTER: Nie M 

PROVIDER: S-EPMC9732011 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature