Lactate regulators contribute to tumor microenvironment and predict prognosis in lung adenocarcinoma.

ABSTRACT:

Background

Lactic acid, as a product of glycolysis, increases tumor cell migration and the invasion of tumor cells in the tumor microenvironment. Besides this, lactic acid promotes the expression of programmed death-1 expression (PD-1) in regulatory T cells, which could cause the failure of PD-1 blockade therapy. However, the implications of lactic acid in the tumor microenvironment of lung adenocarcinoma (LUAD) remain largely unclear.

Methods

We performed unsupervised consensus clustering to identify lactic-associated subtypes using expression profile of lactate regulators in LUAD. Differentially expressed genes (DEGs) associated with lactic-associated subtypes was used to construct lactate signature (LaSig) using LASSO regression algorithm. Immune infiltration analysis was

SUBMITTER: Shang S 

PROVIDER: S-EPMC9732022 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature