GSK3 inhibitor suppresses cell growth and metabolic process in FLT3-ITD leukemia cells.
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ABSTRACT:
SUBMITTER: Xia J
PROVIDER: S-EPMC9732066 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
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GSK3 inhibitor suppresses cell growth and metabolic process in FLT3-ITD leukemia cells.
Xia Jing J Feng Shuxian S Zhou Jian J Zhang Lin L Shi Dingfang D Wang Mengjie M Zhu Yi Y Bu Chaozhi C Xu Daming D Li Tianyu T
Medical oncology (Northwood, London, England) 20221208 1
Glycogen Synthase Kinase-3 (GSK-3) was recently implicated in the dysregulated biology of acute myeloid leukemia (AML). Low concentrations of GSK-3 inhibitors, SB216763 and BIO, suppressed the proliferation of AML cells with FLT3-ITD as early as 24 h after treatment. BIO was used in subsequent assays since it exhibited higher inhibitory effects than SB216763. BIO-induced G1 cell cycle arrest by regulating the expression of cyclin D2 and p21 in MV4-11 cells, and promoted apoptosis by regulating t ...[more]
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