Urinary Leukotriene E4 as a Biomarker in NSAID-Exacerbated Respiratory Disease (N-ERD): a Systematic Review and Meta-analysis.

ABSTRACT:

Purpose of review

Non-steroidal exacerbated respiratory disease (N-ERD) currently requires aspirin challenge testing for diagnosis. Urinary leukotriene E4 (uLTE₄) has been extensively investigated as potential biomarker in N-ERD. We aimed to assess the usefulness of uLTE₄ as a biomarker in the diagnosis of N-ERD.

Recent findings

N-ERD, formerly known as aspirin-intolerant asthma (AIA), is characterised by increased leukotriene production. uLTE₄ indicates cysteinyl leukotriene production, and a potential biomarker in N-ERD. Although several studies and have examined the relationship between uLTE₄ and N-ERD, the usefulness of uLTE₄ as a biomarker in a clinical setting remains unclear.

Findings

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SUBMITTER: Marquette M 

PROVIDER: S-EPMC9732072 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature