Association of circulating miRNAS in patients with Alstrom and Bardet-Biedl syndromes with clinical course parameters.

ABSTRACT:

Background

Patients with the rare syndromic forms of monogenic diabetes: Alström syndrome (ALMS) and Bardet-Biedl syndrome (BBS) have multiple metabolic abnormalities, including early-onset obesity, insulin resistance, lipid disorders and type 2 diabetes mellitus. The aim of this study was to determine if the expression of circulating miRNAs in patients with ALMS and BBS differs from that in healthy and obese individuals and determine if miRNA levels correlate with metabolic tests, BMI-SDS and patient age.

Methods

We quantified miRNA expression (Qiagen, Germany) in four groups of patients: with ALMS (n=13), with BBS (n=7), patients with obesity (n=19) and controls (n=23). Clinical parameters including lipids profile, serum creatinine, cystatin C, fasting glucose, insulin and

SUBMITTER: Zmyslowska A 

PROVIDER: S-EPMC9732093 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature