Causal relationship between particulate matter 2.5 and hypothyroidism: A two-sample Mendelian randomization study.

ABSTRACT:

Background

Epidemiological surveys have found that particulate matter 2.5 (PM_2.5) plays an important role in hypothyroidism. However, due to the methodological limitations of traditional observational studies, it is difficult to make causal inferences. In the present study, we assessed the causal association between PM_2.5 concentrations and risk of hypothyroidism using two-sample Mendelian randomization (TSMR).

Methods

We performed TSMR by using aggregated data from genome-wide association studies (GWAS) on the IEU Open GWAS database. We identified seven single nucleotide polymorphisms (SNPs) associated with PM_2.5 concentrations as instrumental variables (IVs). We used inverse-variance weighting (IVW) as the main analytical method, and we sel

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC9732245 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature