3D printing of cellulose nanocrystals based composites to build robust biomimetic scaffolds for bone tissue engineering.

ABSTRACT: Cellulose nanocrystals (CNC) are drawing increasing attention in the fields of biomedicine and healthcare owing to their durability, biocompatibility, biodegradability and excellent mechanical properties. Herein, we fabricated using fused deposition modelling technology 3D composite scaffolds from polylactic acid (PLA) and CNC extracted from Ficus thonningii. Scanning electron microscopy revealed that the printed scaffolds exhibit interconnected pores with an estimated average pore size of approximately 400 µm. Incorporating 3% (w/w) of CNC into the composite improved PLA mechanical properties (Young's modulus increased by ~ 30%) and wettability (water contact angle decreased by ~ 17%). The mineralization process of printed scaffolds using simulated body fluid was validated and nucleation

SUBMITTER: N'Gatta KM 

PROVIDER: S-EPMC9732347 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature