The role of the tryptophan-NAD + pathway in a mouse model of severe malnutrition induced liver dysfunction.
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ABSTRACT:
SUBMITTER: Hu G
PROVIDER: S-EPMC9732354 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
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The role of the tryptophan-NAD + pathway in a mouse model of severe malnutrition induced liver dysfunction.
Hu Guanlan G Ling Catriona C Chi Lijun L Thind Mehakpreet K MK Furse Samuel S Koulman Albert A Swann Jonathan R JR Lee Dorothy D Calon Marjolein M MM Bourdon Celine C Versloot Christian J CJ Bakker Barbara M BM Gonzales Gerard Bryan GB Kim Peter K PK Bandsma Robert H J RHJ
Nature communications 20221208 1
Mortality in children with severe malnutrition is strongly related to signs of metabolic dysfunction, such as hypoglycemia. Lower circulating tryptophan levels in children with severe malnutrition suggest a possible disturbance in the tryptophan-nicotinamide adenine dinucleotide (TRP-NAD+) pathway and subsequently in NAD+ dependent metabolism regulator sirtuin1 (SIRT1). Here we show that severe malnutrition in weanling mice, induced by 2-weeks of low protein diet feeding from weaning, leads to ...[more]
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