Microbial-derived metabolites induce actin cytoskeletal rearrangement and protect blood-brain barrier function.

ABSTRACT: The gut microbiota influences host brain function, but the underlying gut-brain axis connections and molecular processes remain unclear. One pathway along this bidirectional communication system involves circulating microbially derived metabolites, such as short-chain fatty acids (SCFAs), which include butyrate and propionate. Brain endothelium is the main interface of communication between circulating signals and the brain, and it constitutes the main component of the blood-brain barrier (BBB). Here, we used a well-established in vitro BBB model treated with physiologically relevant concentrations of butyrate and propionate with and without lipopolysaccharide (LPS) to examine the effects of SCFAs on the actin cytoskeleton and tight junction protein structure. Both SCFAs induced dis

SUBMITTER: Knox EG 

PROVIDER: S-EPMC9732410 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature