Estimated Kidney Tubular Secretion and Kidney, Cardiovascular, and Mortality Outcomes in CKD: The Systolic Blood Pressure Intervention Trial.

ABSTRACT:

Rational & objective

Many drugs, metabolites, and toxins are cleared by the kidneys via tubular secretion. Whether novel endogenous measures of tubular secretion provide information about kidney, cardiovascular, and mortality risk is uncertain.

Study design

Longitudinal subgroup analysis of clinical trial participants.

Setting & participants

2,089 Systolic Blood Pressure Intervention Trial participants with estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m² at baseline.

Exposure

Summary score incorporating urine-to-plasma ratios of 10 endogenous secretion markers measured in paired urine and plasma samples at baseline.

Outcome

The primary outcome was longitudinal change in eGFR. Secondary outcomes included chronic kidney disease (C

SUBMITTER: Ascher SB 

PROVIDER: S-EPMC9732413 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature