The Impact of Anticholinergic Use for Overactive Bladder on Cognitive Changes in Adults with Normal Cognition, Mild Cognitive Impairment, or Dementia

ABSTRACT: Take Home Message Use of anticholinergic medication for overactive bladder (OAB) was not associated with a significant decline in markers of cognitive function among a group of individuals with normal or impaired cognition. APOE ε4 allele status did not modify the effect of OAB anticholinergic medications on cognition.

Background

Few studies have addressed whether anticholinergic (AC) medications for overactive bladder (OAB) cause cognitive decline in individuals with existing cognitive impairment, and whether the APOE ε4 gene increases this risk.

Objective

To determine whether OAB AC use is associated with a clinically relevant change in cognitive measures among adults with normal and abnormal cognition.

Design, setting, and participants

This was a retrospective

SUBMITTER: Welk B 

PROVIDER: S-EPMC9732452 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature