Genetic expression changes and pathologic findings associated with hyperhomocysteinemia in human autopsy brain tissue.

ABSTRACT:

Introduction

Vascular contributions to cognitive impairment and dementia (VCID) are a leading cause of dementia. An underappreciated, modifiable risk factor for VCID is hyperhomocysteinemia (HHcy), defined by elevated levels of plasma homocysteine, most often due to impaired B vitamin absorption in aged persons. Studies aimed at identifying neuropathologic features and gene expression profiles associated with HHcy have been lacking.

Methods

A subset of research volunteers from the University of Kentucky Alzheimer's Disease Research Center longitudinal cohort came to autopsy and had ante mortem plasma homocysteine levels available. Brain tissue and blood plasma drawn closest to death were used to measure homocysteine and related metabolites in the current pilot study.

SUBMITTER: Weekman EM 

PROVIDER: S-EPMC9732462 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature