Randomized Clinical Trial Comparing On-clamp Versus Off-clamp Laparoscopic Partial Nephrectomy for Small Renal Masses (CLOCK II Laparoscopic Study): A Intention-to-treat Analysis of Perioperative Outcomes.

ABSTRACT:

Background

Recent randomized trials (RCTs) in the field of robotic partial nephrectomy (PN) showed no significant differences in perioperative outcomes between the off- and on-clamp approaches.

Objective

To compare the perioperative outcomes of on- versus off-clamp pure laparoscopic PN (LPN).

Design setting and participants

A multi-institutional analysis of the on- versus off-clamp approach during LPN in the setting of an RCT (CLOCK II trial; ClinicalTrials.gov NCT02287987) was performed.

Intervention

Off- versus on-clamp LPN.

Outcome measurements and statistical analysis

Baseline patient and tumor variables, and peri- and postoperative data were collected. Randomized allocation with a 1:1 ratio was assigned. Surgical strategy for managing the renal pedi

SUBMITTER: Bertolo R 

PROVIDER: S-EPMC9732468 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature