Humulus lupus extract rich in xanthohumol improves the clinical course in critically ill COVID-19 patients.

ABSTRACT:

Background

The systemic inflammatory response following severe COVID-19 is associated with poor outcomes. Several anti-inflammatory medications have been studied in COVID-19 patients. Xanthohumol (Xn), a natural extract from hop cones, possesses strong anti-inflammatory and antioxidative properties. The aim of this study was to analyze the effect of Xn on the inflammatory response and the clinical outcome of COVID-19 patients.

Methods

Adult patients treated for acute respiratory failure (PaO₂/FiO₂ less than 150) were studied. Patients were randomized into two groups: Xn - patients receiving adjuvant treatment with Xn at a daily dose of 4.5 mg/kg body weight for 7 days, and C - controls. Observations were performed at four time points: immediately after

SUBMITTER: Dabrowski W 

PROVIDER: S-EPMC9732508 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature