Contributions of obesity to kidney health and disease: insights from Mendelian randomization and the human kidney transcriptomics.

ABSTRACT:

Aims

Obesity and kidney diseases are common complex disorders with an increasing clinical and economic impact on healthcare around the globe. Our objective was to examine if modifiable anthropometric obesity indices show putatively causal association with kidney health and disease and highlight biological mechanisms of potential relevance to the association between obesity and the kidney.

Methods and results

We performed observational, one-sample, two-sample Mendelian randomization (MR) and multivariable MR studies in ∼300 000 participants of white-British ancestry from UK Biobank and participants of predominantly European ancestry from genome-wide association studies. The MR analyses revealed that increasing values of genetically predicted body mass index and waist circumfe

SUBMITTER: Xu X 

PROVIDER: S-EPMC9732514 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature