Maladaptive Laterality in Cortical Networks Related to Social Communication in Autism Spectrum Disorder.

ABSTRACT: Neuroimaging studies of individuals with autism spectrum disorders (ASDs) consistently find an aberrant pattern of reduced laterality in brain networks that support functions related to social communication and language. However, it is unclear how the underlying functional organization of these brain networks is altered in ASD individuals. We tested four models of reduced laterality in a social communication network in 70 ASD individuals (14 females) and a control group of the same number of tightly matched typically developing (TD) individuals (19 females) using high-quality resting-state fMRI data and a method of measuring patterns of functional laterality across the brain. We found that a functionally defined social communication network exhibited the typical pattern of left laterality

SUBMITTER: Persichetti AS 

PROVIDER: S-EPMC9732822 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature