Intellectual enrichment and genetic modifiers of cognition and brain volume in Huntington's disease.

ABSTRACT: An important step towards the development of treatments for cognitive impairment in ageing and neurodegenerative diseases is to identify genetic and environmental modifiers of cognitive function and understand the mechanism by which they exert an effect. In Huntington's disease, the most common autosomal dominant dementia, a small number of studies have identified intellectual enrichment, i.e. a cognitively stimulating lifestyle and genetic polymorphisms as potential modifiers of cognitive function. The aim of our study was to further investigate the relationship and interaction between genetic factors and intellectual enrichment on cognitive function and brain atrophy in Huntington's disease. For this purpose, we analysed data from Track-HD, a multi-centre longitudinal study in Huntington

SUBMITTER: Papoutsi M 

PROVIDER: S-EPMC9732861 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature