Direct Access to Unnatural Cyclobutane α-Amino Acids through Visible Light Catalyzed [2+2]-Cycloaddition.

ABSTRACT: In this work, we report the first selective, photocatalyzed [2+2]-cycloaddition of dehydroamino acids with styrene-type olefins. This simple, mild, and scalable approach relies on the use of the triplet energy transfer catalyst [Ir(dFCF₃ppy₂)dtbpy]PF₆ under visible light irradiation and provides fast access to value-added substituted strained cyclobutane α-amino acid derivatives.

SUBMITTER: Stinglhamer M 

PROVIDER: S-EPMC9732878 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature