Dataset Information

An unusual outbreak in the Netherlands: community-onset impetigo caused by a meticillin-resistant Staphylococcus aureus with additional resistance to fusidic acid, June 2018 to January 2020.

ABSTRACT: In this retrospective observational study, we analysed a community outbreak of impetigo with meticillin-resistant Staphylococcus aureus (MRSA), with additional resistance to fusidic acid (first-line treatment). The outbreak occurred between June 2018 and January 2020 in the eastern part of the Netherlands with an epidemiological link to three cases from the north-western part. Forty nine impetigo cases and eight carrier cases were identified, including 47 children. All but one impetigo case had community-onset of symptoms. Pharmacy prescription data for topical mupirocin and fusidic acid and GP questionnaires suggested an underestimated outbreak size. The 57 outbreak isolates were identified by the Dutch MRSA surveillance as MLVA-type MT4627 and sequence type 121, previously reported only once in 2014. Next-generation sequencing revealed they contained a fusidic acid resistance gene, exfoliative toxin genes and an epidermal cell differentiation inhibitor gene. Whole-genome multilocus sequence typing revealed genetic clustering of all 19 sequenced isolates from the outbreak region and isolates from the three north-western cases. The allelic distances between these Dutch isolates and international isolates were high. This outbreak shows the appearance of community-onset MRSA strains with additional drug resistance and virulence factors in a country with a low prevalence of antimicrobial resistance.

SUBMITTER: Vendrik KEW

PROVIDER: S-EPMC9732922 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature

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An unusual outbreak in the Netherlands: community-onset impetigo caused by a meticillin-resistant <i>Staphylococcus aureus</i> with additional resistance to fusidic acid, June 2018 to January 2020.

Vendrik Karuna E W KEW Kuijper Ed J EJ Dimmendaal Marieke M Silvis Welmoed W Denie-Verhaegh Els E de Boer Annemarie A Postma Bent B Schoffelen Annelot F AF Ruijs Wilhelmina L M WLM Koene Fleur M H P A FMHPA Petrignani Mariska M Hooiveld Mariëtte M Witteveen Sandra S Schouls Leo M LM Notermans Daan W DW

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 20221201 49

In this retrospective observational study, we analysed a community outbreak of impetigo with meticillin-resistant <i>Staphylococcus aureus</i> (MRSA), with additional resistance to fusidic acid (first-line treatment). The outbreak occurred between June 2018 and January 2020 in the eastern part of the Netherlands with an epidemiological link to three cases from the north-western part. Forty nine impetigo cases and eight carrier cases were identified, including 47 children. All but one impetigo ca ...[more]

PMID: 36695440

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Project description:BackgroundIntestinal parasites such as Cryptosporidium spp., Giardia lamblia and Entamoeba histolytica can cause severe diarrhea, especially among children in developing countries. This study aims to determine the frequency of Cryptosporidium spp., Giardia lamblia and Entamoeba histolytica in children with diarrhea and identify risk factors for infection.MethodologyWe conducted a cross-sectional study in children aged 0-168 months hospitalized with diarrhea in three regions of Mozambique, from June 2014 to January 2018. Following consent, caretakers were interviewed and a single stool specimen was collected from each child to diagnose Cryptosporidium spp., G. lamblia and E. histolytica using commercial immune-enzymatic assay (TechLab, Inc, Blacksburg, VA, USA). Anthropometric data were collected from the clinical reports. Multivariable logistic regression models were built to identify risk factors for Cryptosporidium spp. and G. lamblia infection.ResultsTwenty-one percent of all specimens (212/1008) presented at least one parasitic infection. Cryptosporidium spp. infection was the most common 12.0% (118/985), followed by G. lamblia 9.7% (95/983) and E. histolytica 2.0% (20/1004). Risk factors for infection by Cryptosporidium spp. were: provenience (children from Nampula province showed the highest risk, OR: 8.176; CI: 1.916-34.894; p-value < 0.01); animal contact (children with animal contact had a protective effect OR: 0.627; CI: 0.398-0.986; p-value < 0.05); underweight (children severely underweight showed a risk of 2.309; CI: 1.310-4.069; p-value < 0.05). Risk factors for infection by G. lamblia were: age (group with highest risk, 60-168 months (OR: 2.322; CI: 1.000-5.393, p-value > 0.05)); and living in a household with five or more members (OR: 2.141; CI: 1.286-3.565, p-value < 0.01).ConclusionsParasitic infection is common among children with diarrhea. Routine testing, standard treatment, and assessment for risk exposure of children with diarrhea should be implemented at health facilities in Mozambique.

Project description:Foot and mouth disease (FMD) is a contagious and economically important viral disease of cloven hoofed animals caused by FMD virus. This retrospective study was conducted to determine the spatio-temporal distribution, estimate the morbidity and case fatality of FMD outbreaks in Western Amhara region of Ethiopia from January 2018 to June 2023. The FMD outbreaks reported to Bahir Dar regional laboratory and confirmed by Sandwich ELISA were used for this study. A total of 164 FMD outbreaks were reported in Western Amhara region of Ethiopia between 2018 and 2023. The highest and lowest number of FMD outbreaks were reported in 2022 (n = 42 outbreaks) and 2018 (n = 9), respectively; however, there was no statistically significant difference in the occurrence of FMD outbreaks between years (p = 0.224). There was no significant difference in case fatality and morbidity rates between years (p> 0.05). Based on months, high number of outbreaks were reported during January (n = 32) across all years and the lowest during April, June and September (n = 3 for each district). There was statistically significant difference in the occurrence of FMD outbreaks between months (p < 0.001). On average, 13.66 FMD outbreaks were reported in each month. All administrative zones in Western Amhara region reported more than one FMD outbreaks during January 2018 -June 2023. The highest and lowest outbreaks were reported from East Gojjam Zone (62 outbreaks/6 district years), and Bahirdar Special Zone and Gondar Town (2 outbreaks for each district). There was no statistically significant difference in the occurrence of FMD outbreaks between the administrative zones (p > 0.05). District wise, the highest and lowest number of FMD outbreaks were reported from Goncha Siso district (n = 14) and Banja, Simada, Zigem, Machakel, Debre Elias and Debark (with one outbreak in each district). This study indicated that FMD outbreaks regular occurs in Western Amhara region. To reduce the occurrence and spreading, animal movement and transport should be controlled, and vaccination should be implemented regularly.

Dataset Information

An unusual outbreak in the Netherlands: community-onset impetigo caused by a meticillin-resistant Staphylococcus aureus with additional resistance to fusidic acid, June 2018 to January 2020.

Publications

An unusual outbreak in the Netherlands: community-onset impetigo caused by a meticillin-resistant <i>Staphylococcus aureus</i> with additional resistance to fusidic acid, June 2018 to January 2020.

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