Gold nanoparticle delivery to solid tumors: a multiparametric study on particle size and the tumor microenvironment.

ABSTRACT: Nanoparticle (NP) delivery to solid tumors remains an actively studied field, where several recent studies have shed new insights into the underlying mechanisms and the still overall poor efficacy. In the present study, Au NPs of different sizes were used as model systems to address this topic, where delivery of the systemically administered NPs to the tumor as a whole or to tumor cells specifically was examined in view of a broad range of tumor-associated parameters. Using non-invasive imaging combined with histology, immunohistochemistry, single-cell spatial RNA expression and image-based single cell cytometry revealed a size-dependent complex interaction of multiple parameters that promoted tumor and tumor-cell specific NP delivery. Interestingly, the data show that most NPs are sequest

SUBMITTER: Izci M 

PROVIDER: S-EPMC9733103 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature