Ontology highlight
ABSTRACT:
SUBMITTER: Xu RC
PROVIDER: S-EPMC9733131 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
Xu Ru-Chen RC Wang Fu F Sun Jia-Lei JL Abuduwaili Weinire W Zhang Guang-Cong GC Liu Zhi-Yong ZY Liu Tao-Tao TT Dong Ling L Shen Xi-Zhong XZ Zhu Ji-Min JM
Journal of translational medicine 20221209 1
Primary liver cancer (PLC) is a common gastrointestinal malignancy worldwide. While hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) are two major pathologic types of PLC, combined HCC and ICC (cHCC-ICC) is a relatively rare subtype that shares both hepatocyte and cholangiocyte differentiation. However, the molecular feature of this unique tumor remains elusive because of its low incidence and lack of a suitable animal model. Herein, we generated a novel spontaneous cHCC- ...[more]